In [[2032]], a manned [[Earth]] mission to Mars, the ''[[Ares IV]]'', took place under the command of Lieutenant [[John Kelly]]. In [[2269]], [[James T. Kirk]] argued in favor of having [[Sargon]] and his companions take over the bodies of the crew, and emphasized the benefits that it might possibly have on mankind, he explained, "''they used to say if man could fly, he'd have wings. But he did fly. He discovered he had to. Do you wish that the first [[Apollo 11|Apollo mission]] hadn't reached the moon or that we hadn't gone on to Mars or the nearest star?''"
In [[2372]], Captain [[Benjamin Sisko]] and [[Constable]] [[Odo]] planned for [[Joseph Sisko]] and [[{{MA|Jake_Sisko|Jake Sisko]] }} to take a transport to Mars to avoid being caught in Admiral [[Leyton]]'s ''[[coup d'état]]''. =
The [[Kyrians]] in [[3074]] believed that Mars was the home of the {{USS|Voyager}}, and not Earth as was the truth. A backup version of [[The Doctor]] corrected this error.