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Isoboramine (also spelled as isoboromine) is a neurotransmitter in Trill physiology which regulates the connections between the host and the symbiont. Low isoboramine levels are harmful and may be fatal to the host and/or symbiont, so if isoboramine levels drop below 40%, then the symbiont is removed. This will kill the host, but any joined Trill will willingly sacrifice themselves in order to save their symbiont.

Benzocyatizine can sometimes be used to treat low isoboramine levels.