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- September 29 – Death of Pavel Popovich, Soviet cosmonaut.
- October 9 – First lunar impact of the Centaur and LCROSS spacecrafts as part of NASA's Lunar Precursor Robotic Program.
- October 28 – NASA successfully launches the Ares I-X mission, the only rocket launch for its later-cancelled Constellation program.
- October 29 – The American Galileo spacecraft makes its closest approach to 951 Gaspra, becoming the first probe to visit an asteroid.