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- John F. Kennedy begins his term as the 35th President of the United States. He later gives his famous "Decision to Go to the Moon" speech.
- In 2372, Jake Sisko (External Link) received a holosuite program from Nog featuring this season's New York Yankees baseball team against the 1978 Boston Red Sox. The outcome of the game was Yankees 7, Red Sox 3.
- October 27 – NASA launches the first Saturn I rocket in Mission Saturn-Apollo 1.